ELEVATED ENHANCER-ONCOGENE CONTACTS AND HIGHER ONCOGENE EXPRESSION LEVELS BY RECURRENT CTCF INACTIVATING MUTATIONS IN ACUTE T CELL LEUKEMIA

Elevated enhancer-oncogene contacts and higher oncogene expression levels by recurrent CTCF inactivating mutations in acute T cell leukemia

Summary: Monoallelic inactivation of CCCTC-binding factor (CTCF) in human cancer drives altered methylated genomic states, altered CTCF occupancy at promoter and enhancer regions, and deregulated global gene expression.In patients with T cell acute lymphoblastic leukemia (T-ALL), we find that acquired 1262 monoallelic CTCF-inactivating events drive

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Variation of air condition parameters, in the conditions of the presence of carbon monoxide, in the duct of ventilation installations

Industrial ventilation and air conditioning systems aim to ensure the conditions of air purity and microclimate corresponding to the activity of man and the nature of the technological process.The parameters of the state of the air which are of interest for the technique of Xbox Series X ventilation and air conditioning are: air temperature and hum

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